* The Bipolar Genetic Study at Columbia University is looking for families with at least two living members who have had a manic episode. 1-888-219-2140 (toll-free) or 1-212-543-2147, email: bipolar@pi.cpmc.columbia.edu and visit Web site at www.bipolar.hs.columbia.edu.

* National Institute of Mental Health, Intramural Research Program, National Institutes of Health, Department of Health and Human Services. Looking for families with two or more siblings with bipolar illness. Diane Kazuba, toll-free, at 1-866-NIH-GENES (1-866-644-4363), or email: kazubad@intra.nimh.nih.gov

* NIMH: Adults with Bipolar Disorder and Depression - There are opportunities to participate in clinical trials exploring the research effects of novel therapeutics compared to placebo for the treatment of depression and bipolar disorder. Several of these trials look at treatment-resistant mood disorders. Volunteers over the age of 18 may be eligible. The studies are conducted at the National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, in Bethesda, Maryland. Atendemos pacientes de hable hispana. Call 301-496-5645 or 1-866-627-6464 (TTY: 1-866-411-1010).

* NIMH Child and Adolescent Bipolar Disorder Study - The National Institute of Mental Health is seeking boys and girls ages 6 to 17 to participate in a study of bipolar disorder in children and adolescents. The study includes a five-day outpatient assessment and infrequent research follow-up visits over four years at the NIH Clinical Center in Bethesda, MD.

* Participants must be: -In treatment with a psychiatrist for bipolar disorder
-On stable medications for the first 6 weeks of the study
-Able to fill out daily self-rating forms and cooperate with study procedures (including genetics studies, MRI, psychological testing, and others)

A thorough evaluation at NIMH is provided free of charge. Travel and lodging expenses are paid for by NIMH. For more information, call 301-496-5645 (TTY: 1-866-411-1010).

* NIMH Children and Adolescents with Bipolar Disorder - The National Institute of Mental Health is conducting a study for treatment-resistant bipolar disorder.

* Participants will receive:
--Clinical and psychological assessments (including an inpatient assessment during which children will be withdrawn from medication)
-Treatment with clozapine or placebo
-Brain imaging (no radiation)

* Participants must:
-Be between the ages of 8 to 17 with bipolar disorder
-Not have done well on lithium, sodium valproate, carbamazepine, and at least one of the newer neuroleptics, as well as a combination of two of these medications

* All procedures are free of cost. Travel expenses are paid for. Call Robinder Bhangoo, M.D., or Ellen Leibenluft, M.D., at (301) 496-8381 or (TTY 1-866-411-1010).